Jadavji Laboratory - Apoptosis and Brain Dervived Neurotrophic Factor

Journal article

M. Esfandiarei, Faizan Anwar, Manogna Nuthi, Alisha Harrison, M. Barrameda, Tala Curry-Koski, Kasey Pull, T. Currier Thomas, N. Jadavji
microPublication Biology, 2025

Semantic Scholar DOI PubMedCentral PubMed

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APA Click to copy
Esfandiarei, M., Anwar, F., Nuthi, M., Harrison, A., Barrameda, M., Curry-Koski, T., … Jadavji, N. (2025). Apoptosis and Brain Dervived Neurotrophic Factor are increased in cortical neurons of Marfan Syndrome mice. MicroPublication Biology.

Chicago/Turabian Click to copy
Esfandiarei, M., Faizan Anwar, Manogna Nuthi, Alisha Harrison, M. Barrameda, Tala Curry-Koski, Kasey Pull, T. Currier Thomas, and N. Jadavji. “Apoptosis and Brain Dervived Neurotrophic Factor Are Increased in Cortical Neurons of Marfan Syndrome Mice.” microPublication Biology (2025).

MLA Click to copy
Esfandiarei, M., et al. “Apoptosis and Brain Dervived Neurotrophic Factor Are Increased in Cortical Neurons of Marfan Syndrome Mice.” MicroPublication Biology, 2025.

BibTeX Click to copy

@article{m2025a,
  title = {Apoptosis and Brain Dervived Neurotrophic Factor are increased in cortical neurons of Marfan Syndrome mice},
  year = {2025},
  journal = {microPublication Biology},
  author = {Esfandiarei, M. and Anwar, Faizan and Nuthi, Manogna and Harrison, Alisha and Barrameda, M. and Curry-Koski, Tala and Pull, Kasey and Thomas, T. Currier and Jadavji, N.}
}

Abstract

Marfan Syndrome (MFS) is an autosomal dominant genetic disorder that affects connective tissue throughout the body due to mutations in the fibrillin-1 ( FBN1) gene. There is a gap in our understanding of the impact of monogenic connective tissue aberrations on the brain. This study aimed to determine the impact of MFS on neurodegeneration in the cortical brain tissue of mice. We report increased levels of apoptosis in neurons within the sensory and motor cortical areas of female MFS mice. Additionally, we also report increased levels of neuronal plasticity in cortical brain tissue of both male and female MFS mice.